การวิเคราะห์ความสัมพันธ์ระหว่างภาวะพหุสัณฐานของ Cytochrome P450 ต่อการเกิดอาการอัน ไม่พงึประสงค์ร้ายแรงทางผิวหนังของ phenytoinในผู้ป่วยเดก็โรคลมชัก Association analysis of Cytochrome P450 Polymorphisms in Phenytoin induced Severe- Cutaneous Adverse Reactions (SCARS) in Young Epileptic Patients

This study was aimed to examine the relationship between CYP2Cs genes on chromosome 10, which control the enzyme activities of cytochrome P450, and the occurrence of phenytoin induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children. DNA samples from SCARs and tolerances. Single Nucleotide polymorphisms (SNPs) composing of rs1592037 (CYP2C8), rs17110192 (CYP2C18), and rs3758581 (CYP2C19) were genotyped by allelespecific PCR. Significant associations were observed between heterozygous genotypes for mutant allele located on rs3758581 and rs17110192 and phenytoin-induced SCARs in Thai epilepsy pediatric patient (OR = 14.52; 95 % CI 1.18 – infinity, p value = 0.044).